Clinical Practice Associated with a Switch from and to Ziprasidone during Routine Inpatient Treatment of Patients with Schizophrenia
Author
Source
Schizophrenia Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Ziprasidone (ZIP) shows a low propensity for metabolic side effects but can prolong QTc time.
It is unclear how these features translate into clinical reality.
Charts of inpatients with schizophrenia and switched from (ZIP−,n=27) or to ZIP (ZIP+,n=24) were reviewed.
Clinical data including documented switch reasons were anonymously analyzed.
Comorbidity, body mass index (BMI) at admission, illness severity, side effects, illness duration, and length of stay were comparable in both groups.
About 2/3 of ZIP+ were women (1/3 of ZIP−,P=0.035); ZIP+ patients were younger (P=0.017), had higher BMI values (P=0.042), and received higher chlorpromazine equivalents before switch (P=0.004) whereas ZIP doses were comparable (136 versus 141 mg/d).
More patients in ZIP− versus ZIP+ were switched because of previous weight gain (P=0.006) and depression (P=0.085) whereas single reasons for ZIP− versus ZIP+ were mainly persisting positive symptoms (P=0.089) and patients' choice (P=0.10).
The results of the naturalistic study corroborate controlled trials.
American Psychological Association (APA)
Müller, Matthias J.. 2011. Clinical Practice Associated with a Switch from and to Ziprasidone during Routine Inpatient Treatment of Patients with Schizophrenia. Schizophrenia Research and Treatment،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-462995
Modern Language Association (MLA)
Müller, Matthias J.. Clinical Practice Associated with a Switch from and to Ziprasidone during Routine Inpatient Treatment of Patients with Schizophrenia. Schizophrenia Research and Treatment No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-462995
American Medical Association (AMA)
Müller, Matthias J.. Clinical Practice Associated with a Switch from and to Ziprasidone during Routine Inpatient Treatment of Patients with Schizophrenia. Schizophrenia Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-462995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462995
