Elevated Levels of IL-10 and G-CSF Associated with Asymptomatic Malaria in Pregnant Women
Joint Authors
Anderson, Winston
Jiang, Yi
Adjei, Andrew A.
Solomon, Wesley
Yatich, Nelly
Stiles, Jonathan K.
Shuaib, Faisal
Jolly, Pauline
Bythwood, Tameka
Wilson, Nana O.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In sub-Saharan Africa, approximately 30 million pregnant women are at risk of contracting malaria annually.
Nearly 36% of healthy pregnant women receiving routine antenatal care tested positive for Plasmodium falciparum HRP-II antigen in Ghana.
We tested the hypothesis that asymptomatic HRP II positive pregnant women expressed a unique Th1 and Th2 phenotype that differs from healthy controls.
Plasma from healthy (n=15) and asymptomatic (n=25) pregnant women were evaluated for 27 biomarkers (IL-1b, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12, IL-13, IL-15, IL- 17, Eotaxin, bFGF-2, G-CSF, GM-CSF, IFN-γ, IP-10, MCP-1, MIP-1α, MIP-1β, PDGF-bb, RANTES, TNF, and VEGF) associated with Th1 and Th2 cytokine homeostasis.
IL-10 and G-CSF levels were elevated in the asymptomatic group when compared with the healthy group (P=.031 and .041, resp.).
The median ratios of IL-1β:5, IL-1β:10, IL-1β:G-CSF, IL-1β:Eotaxin, IL-12:G-CSF, IL-15:10, IL-17:G-CSF, IL-17:Eotaxin, TNF:IL-4, TNF:IL-5, and TNF:G-CSF were significantly different among the two groups.
Thus, asymptomatic malaria carriage may be linked to circulating levels of IL-10 and G-CSF.
American Psychological Association (APA)
Wilson, Nana O.& Bythwood, Tameka& Solomon, Wesley& Jolly, Pauline& Yatich, Nelly& Jiang, Yi…[et al.]. 2010. Elevated Levels of IL-10 and G-CSF Associated with Asymptomatic Malaria in Pregnant Women. Infectious Diseases in Obstetrics and Gynecology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-463001
Modern Language Association (MLA)
Wilson, Nana O.…[et al.]. Elevated Levels of IL-10 and G-CSF Associated with Asymptomatic Malaria in Pregnant Women. Infectious Diseases in Obstetrics and Gynecology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-463001
American Medical Association (AMA)
Wilson, Nana O.& Bythwood, Tameka& Solomon, Wesley& Jolly, Pauline& Yatich, Nelly& Jiang, Yi…[et al.]. Elevated Levels of IL-10 and G-CSF Associated with Asymptomatic Malaria in Pregnant Women. Infectious Diseases in Obstetrics and Gynecology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-463001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463001