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Escalation with Overdose Control Using Ordinal Toxicity Grades for Cancer Phase I Clinical Trials
Joint Authors
Cook-Wiens, Galen
Rogatko, André
Tighiouart, Mourad
Source
Journal of Probability and Statistics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-31
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
We extend a Bayesian adaptive phase I clinical trial design known as escalation with overdose control (EWOC) by introducing an intermediate grade 2 toxicity when assessing dose-limiting toxicity (DLT).
Under the proportional odds model assumption of dose-toxicity relationship, we prove that in the absence of DLT, the dose allocated to the next patient given that the previously treated patient had a maximum of grade 2 toxicity is lower than the dose given to the next patient had the previously treated patient exhibited a grade 0 or 1 toxicity at the most.
Further, we prove that the coherence properties of EWOC are preserved.
Simulation results show that the safety of the trial is not compromised and the efficiency of the estimate of the maximum tolerated dose (MTD) is maintained relative to EWOC treating DLT as a binary outcome and that fewer patients are overdosed using this design when the true MTD is close to the minimum dose.
American Psychological Association (APA)
Tighiouart, Mourad& Cook-Wiens, Galen& Rogatko, André. 2012. Escalation with Overdose Control Using Ordinal Toxicity Grades for Cancer Phase I Clinical Trials. Journal of Probability and Statistics،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-463027
Modern Language Association (MLA)
Tighiouart, Mourad…[et al.]. Escalation with Overdose Control Using Ordinal Toxicity Grades for Cancer Phase I Clinical Trials. Journal of Probability and Statistics No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-463027
American Medical Association (AMA)
Tighiouart, Mourad& Cook-Wiens, Galen& Rogatko, André. Escalation with Overdose Control Using Ordinal Toxicity Grades for Cancer Phase I Clinical Trials. Journal of Probability and Statistics. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-463027
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463027