Novel Insights into the Interplay between Apoptosis and Autophagy
Author
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
For several decades, apoptosis has taken center stage as the principal mechanism of programmed cell death (type I cell death) in mammalian tissues.
Autophagic cell death (type II) is characterized by the massive accumulation of autophagic vacuoles in the cytoplasm of cells.
The autophagic process is activated as an adaptive response to a variety of extracellular and intracellular stresses, including nutrient deprivation, hormonal or therapeutic treatment, pathogenic infection, aggregated and misfolded proteins, and damaged organelles.
Increasing evidence indicates that autophagy is associated with a number of pathological processes, including cancer.
The regulation of autophagy in cancer cells is complex since it can enhance cancer cell survival in response to certain stresses, while it can also act to suppress the initiation of cancer growth.
This paper focused on recent advances regarding autophagy in cancer and the techniques currently available to manipulate autophagy.
American Psychological Association (APA)
Rikiishi, Hidemi. 2012. Novel Insights into the Interplay between Apoptosis and Autophagy. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-463030
Modern Language Association (MLA)
Rikiishi, Hidemi. Novel Insights into the Interplay between Apoptosis and Autophagy. International Journal of Cell Biology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-463030
American Medical Association (AMA)
Rikiishi, Hidemi. Novel Insights into the Interplay between Apoptosis and Autophagy. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-463030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463030