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The Role of microRNAs in the Regulation of Apoptosis in Lung Cancer and Its Application in Cancer Treatment
Joint Authors
Othman, Norahayu
Nagoor, Noor Hasima
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Lung cancer remains to be one of the most common and serious types of cancer worldwide.
While treatment is available, the survival rate of this cancer is still critically low due to late stage diagnosis and high frequency of drug resistance, thus highlighting the pressing need for a greater understanding of the molecular mechanisms involved in lung carcinogenesis.
Studies in the past years have evidenced that microRNAs (miRNAs) are critical players in the regulation of various biological functions, including apoptosis, which is a process frequently evaded in cancer progression.
Recently, miRNAs were demonstrated to possess proapoptotic or antiapoptotic abilities through the targeting of oncogenes or tumor suppressor genes.
This review examines the involvement of miRNAs in the apoptotic process of lung cancer and will also touch on the promising evidence supporting the role of miRNAs in regulating sensitivity to anticancer treatment.
American Psychological Association (APA)
Othman, Norahayu& Nagoor, Noor Hasima. 2014. The Role of microRNAs in the Regulation of Apoptosis in Lung Cancer and Its Application in Cancer Treatment. BioMed Research International،Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-463060
Modern Language Association (MLA)
Othman, Norahayu& Nagoor, Noor Hasima. The Role of microRNAs in the Regulation of Apoptosis in Lung Cancer and Its Application in Cancer Treatment. BioMed Research International No. 2014 (2014), pp.1-19.
https://search.emarefa.net/detail/BIM-463060
American Medical Association (AMA)
Othman, Norahayu& Nagoor, Noor Hasima. The Role of microRNAs in the Regulation of Apoptosis in Lung Cancer and Its Application in Cancer Treatment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-463060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463060