Etiological Analysis of Neurodevelopmental Disabilities : Single-Center Eight-Year Clinical Experience in South China
Joint Authors
Kobayashi, Keiko
Wang, Zi-Neng
Jiang, Jian-Hui
Song, Yuan-Zong
Deng, Mei
Tan, Yue-Qiu
Li, Bing-Xiao
Zhang, Chun-Hua
Guo, Li
Wen, Fang
Liu, Zhen-Huan
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Etiology determination of neurodevelopmental disabilities (NDDs) currently remains a worldwide common challenge on child health.
We herein reported the etiology distribution feature in a cohort of 285 Chinese patients with NDDs.
Although concrete NDD etiologies in 48.4% of the total patients could not be identified, genetic diseases (with the proportion of 35.8% in the total cases) including inborn errors of metabolism (IEM) and congenital dysmorphic diseases, constituted the commonest etiology category for NDDs in this study.
The two key experimental technologies in pediatric metabolomics, gas chromatography-mass spectrometry (GC-MS), and tandem mass spectrometry (MS-MS), proved to be substantially helpful for the exploration of the NDD etiologies in this clinical investigation.
The findings in this paper provided latest epidemiologic information on the etiology distribution of NDDs in Chinese, and the syndromic NDDs caused by citrin deficiency and the novel chromosomal karyotype, respectively, further expanded the etiology spectrum of NDDs.
American Psychological Association (APA)
Guo, Li& Li, Bing-Xiao& Deng, Mei& Wen, Fang& Jiang, Jian-Hui& Tan, Yue-Qiu…[et al.]. 2010. Etiological Analysis of Neurodevelopmental Disabilities : Single-Center Eight-Year Clinical Experience in South China. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-463119
Modern Language Association (MLA)
Guo, Li…[et al.]. Etiological Analysis of Neurodevelopmental Disabilities : Single-Center Eight-Year Clinical Experience in South China. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-463119
American Medical Association (AMA)
Guo, Li& Li, Bing-Xiao& Deng, Mei& Wen, Fang& Jiang, Jian-Hui& Tan, Yue-Qiu…[et al.]. Etiological Analysis of Neurodevelopmental Disabilities : Single-Center Eight-Year Clinical Experience in South China. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-463119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463119