Evidence of Antidepressive Effects of a Wakan-yaku, Hochuekkito, in Depression Model Mice with Learned-Helplessness Behavior
Joint Authors
Tohda, Michihisa
Mingmalairak, Salin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Wakan-yaku is a type of Japanese and Sino traditional, systematized medical care that has been practiced for hundreds of years.
This medicinal system includes many antidepressive prescriptions.
One of the candidates is Hochuekkito, although experimental evidence has not yet been established clearly.
To obtain evidence, a depression model of learned-helplessness (LH) mice was used.
Based on the score of escape failure, an index of the depression degree, mice with a depressive condition were selected to assess Hochuekkito’s effects.
This selection was significant and effective in the following two points: evaluation of the drug effect under disease conditions and minimization of the number of animals.
Treatment with Hochuekkito (1 and 5 g/kg p.o.; estimated galenical amount) for 14 days significantly decreased the depression index, the number of escape failures, and desipramine (10 mg/kg p.o.) suggesting that Hochuekkito has an antidepressive effect.
American Psychological Association (APA)
Tohda, Michihisa& Mingmalairak, Salin. 2013. Evidence of Antidepressive Effects of a Wakan-yaku, Hochuekkito, in Depression Model Mice with Learned-Helplessness Behavior. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-463143
Modern Language Association (MLA)
Tohda, Michihisa& Mingmalairak, Salin. Evidence of Antidepressive Effects of a Wakan-yaku, Hochuekkito, in Depression Model Mice with Learned-Helplessness Behavior. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-463143
American Medical Association (AMA)
Tohda, Michihisa& Mingmalairak, Salin. Evidence of Antidepressive Effects of a Wakan-yaku, Hochuekkito, in Depression Model Mice with Learned-Helplessness Behavior. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-463143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463143