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Binding of Host Factors Influences Internalization and Intracellular Trafficking of Streptococcus uberis in Bovine Mammary Epithelial Cells
Joint Authors
Oliver, Stephen P.
Almeida, Raul A.
Dunlap, John R.
Source
Veterinary Medicine International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We showed that internalization of Streptococcus uberis into bovine mammary epithelial cells occurred through receptor- (RME) and caveolae-mediated endocytosis (CME).
We reported also that treatment of S.
uberis with host proteins including lactoferrin (LF) enhanced its internalization into host cells.
Since the underlying mechanism(s) involved in such enhancement was unknown we investigated if preincubation of S.
uberis with host proteins drives internalization of this pathogen into host cells through CME.
Thus, experiments involving coculture of collagen-, fibronectin-, and LF-pretreated S.
uberis with bovine mammary epithelial cells treated with RME and CME inhibitors were conducted.
Results showed that internalization of host proteins-pretreated S.
uberis into mammary epithelial cells treated with RME inhibitors was higher than that of untreated controls.
These results suggest that pretreatment with selected host proteins commits S.
uberis to CME, thus avoiding intracellular bactericidal mechanisms and allowing its persistence into bovine mammary epithelial cells.
American Psychological Association (APA)
Almeida, Raul A.& Dunlap, John R.& Oliver, Stephen P.. 2010. Binding of Host Factors Influences Internalization and Intracellular Trafficking of Streptococcus uberis in Bovine Mammary Epithelial Cells. Veterinary Medicine International،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-463155
Modern Language Association (MLA)
Almeida, Raul A.…[et al.]. Binding of Host Factors Influences Internalization and Intracellular Trafficking of Streptococcus uberis in Bovine Mammary Epithelial Cells. Veterinary Medicine International No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-463155
American Medical Association (AMA)
Almeida, Raul A.& Dunlap, John R.& Oliver, Stephen P.. Binding of Host Factors Influences Internalization and Intracellular Trafficking of Streptococcus uberis in Bovine Mammary Epithelial Cells. Veterinary Medicine International. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-463155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463155