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Focal Adhesion-Chromatin Linkage Controls Tumor Cell Resistance to Radio- and Chemotherapy
Joint Authors
Source
Chemotherapy Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cancer resistance to therapy presents an ongoing and unsolved obstacle, which has clear impact on patient's survival.
In order to address this problem, novel in vitro models have been established and are currently developed that enable data generation in a more physiological context.
For example, extracellular-matrix- (ECM-) based scaffolds lead to the identification of integrins and integrin-associated signaling molecules as key promoters of cancer cell resistance to radio- and chemotherapy as well as modern molecular agents.
In this paper, we discuss the dynamic nature of the interplay between ECM, integrins, cytoskeleton, nuclear matrix, and chromatin organization and how this affects the response of tumor cells to various kinds of cytotoxic anticancer agents.
American Psychological Association (APA)
Storch, Katja& Cordes, Nils. 2012. Focal Adhesion-Chromatin Linkage Controls Tumor Cell Resistance to Radio- and Chemotherapy. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-463171
Modern Language Association (MLA)
Storch, Katja& Cordes, Nils. Focal Adhesion-Chromatin Linkage Controls Tumor Cell Resistance to Radio- and Chemotherapy. Chemotherapy Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-463171
American Medical Association (AMA)
Storch, Katja& Cordes, Nils. Focal Adhesion-Chromatin Linkage Controls Tumor Cell Resistance to Radio- and Chemotherapy. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-463171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463171