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Cardiovascular Risk in Chronic Kidney Disease : Role of the Sympathetic Nervous System
Author
Source
Cardiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Patients with chronic kidney disease are at significantly increased risk for cardiovascular disease and sudden cardiac death.
One mechanism underlying increased cardiovascular risk in patients with renal failure includes overactivation of the sympathetic nervous system (SNS).
Multiple human and animal studies have shown that central sympathetic outflow is chronically elevated in patients with both end-stage renal disease (ESRD) and chronic kidney disease (CKD).
SNS overactivation, in turn, increases the risk of cardiovascular disease and sudden death by increasing arterial blood pressure, arrythmogenicity, left ventricular hypertrophy, and coronary vasoconstriction and contributes to the progression renal disease.
This paper will examine the evidence for SNS overactivation in renal failure from both human and experimental studies and discuss mechanisms of SNS overactivity in CKD and therapeutic implications.
American Psychological Association (APA)
Park, Jeanie. 2012. Cardiovascular Risk in Chronic Kidney Disease : Role of the Sympathetic Nervous System. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-463183
Modern Language Association (MLA)
Park, Jeanie. Cardiovascular Risk in Chronic Kidney Disease : Role of the Sympathetic Nervous System. Cardiology Research and Practice No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-463183
American Medical Association (AMA)
Park, Jeanie. Cardiovascular Risk in Chronic Kidney Disease : Role of the Sympathetic Nervous System. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-463183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463183