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BLM Deficiency Is Not Associated with Sensitivity to Hydroxyurea-Induced Replication Stress
Joint Authors
Lahkim Bennani-Belhaj, Kenza
Onclercq-Delic, Rosine
Jmari, Nada
Amor-Guéret, Mounira
Buhagiar-Labarchède, Géraldine
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bloom's syndrome (BS) displays one of the strongest known correlations between chromosomal instability and a high risk of cancer at an early age.
BS cells combine a reduced average fork velocity with constitutive endogenous replication stress.
However, the response of BS cells to replication stress induced by hydroxyurea (HU), which strongly slows the progression of replication forks, remains unclear due to publication of conflicting results.
Using two different cellular models of BS, we showed that BLM deficiency is not associated with sensitivity to HU, in terms of clonogenic survival, DSB generation, and SCE induction.
We suggest that surviving BLM-deficient cells are selected on the basis of their ability to deal with an endogenous replication stress induced by replication fork slowing, resulting in insensitivity to HU-induced replication stress.
American Psychological Association (APA)
Lahkim Bennani-Belhaj, Kenza& Buhagiar-Labarchède, Géraldine& Jmari, Nada& Onclercq-Delic, Rosine& Amor-Guéret, Mounira. 2010. BLM Deficiency Is Not Associated with Sensitivity to Hydroxyurea-Induced Replication Stress. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-463216
Modern Language Association (MLA)
Lahkim Bennani-Belhaj, Kenza…[et al.]. BLM Deficiency Is Not Associated with Sensitivity to Hydroxyurea-Induced Replication Stress. Journal of Nucleic Acids No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-463216
American Medical Association (AMA)
Lahkim Bennani-Belhaj, Kenza& Buhagiar-Labarchède, Géraldine& Jmari, Nada& Onclercq-Delic, Rosine& Amor-Guéret, Mounira. BLM Deficiency Is Not Associated with Sensitivity to Hydroxyurea-Induced Replication Stress. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-463216
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463216