Role of Bacterial Lipopolysaccharide in Enhancing Host Immune Response to Candida albicans
Joint Authors
Lewis, Michael A. O.
Feng, Gui-Jie
Wei, Xiao-Qing
Rogers, Helen
Williams, David W.
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Human infections involving yeast of the genus Candida often occur in the presence of bacteria, and, as such, it is important to understand how these bacteria influence innate host immunity towards Candida.
Dectin-1 is a cell receptor of macrophages for Candida albicans recognition.
The aim of this study was to examine dectin-1 expression by monocytes after stimulation with bacterial lipopolysaccharide (LPS), followed by heat-killed C.
albicans (HKC).
Freshly isolated human peripheral blood monocytes (PBMCs) and human monocytes cell line (THP-1) cells expressed low levels of dectin-1.
Stimulation with LPS and GM-CSF/IL-4 was found to increase dectin-1 expression in both CD14+ human PBMC and THP-1 cells.
Enhanced dectin-1 expression resulted in increased phagocytosis of Candida.
When THP-1 cells were challenged only with HKC, detectable levels of IL-23 were not evident.
However, challenge by LPS followed by varying concentrations of HKC resulted in increased IL-23 expression by THP-1 cells in HKC dose-dependent manner.
Increased expression of IL-17 by PBMC also occurred after stimulation with Candida and LPS.
In conclusion, bacterial LPS induces an enhanced immune response to Candida by immune cells, and this occurs through increasing dectin-1 expression.
American Psychological Association (APA)
Rogers, Helen& Williams, David W.& Feng, Gui-Jie& Lewis, Michael A. O.& Wei, Xiao-Qing. 2013. Role of Bacterial Lipopolysaccharide in Enhancing Host Immune Response to Candida albicans. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-463237
Modern Language Association (MLA)
Rogers, Helen…[et al.]. Role of Bacterial Lipopolysaccharide in Enhancing Host Immune Response to Candida albicans. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-463237
American Medical Association (AMA)
Rogers, Helen& Williams, David W.& Feng, Gui-Jie& Lewis, Michael A. O.& Wei, Xiao-Qing. Role of Bacterial Lipopolysaccharide in Enhancing Host Immune Response to Candida albicans. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-463237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463237