Radiolabeled Somatostatin Analogues Therapy in Advanced Neuroendocrine Tumors : A Single Centre Experience
Joint Authors
Sollini, M.
Grassi, E.
Erba, P. A.
Versari, A.
Frasoldati, A.
Massi, L.
Froio, A.
Filice, A.
Asti, M.
Fraternali, A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study was to assess the efficacy of PRRT in patients with advanced neuroendocrine tumors (NETs).
Patients and Methods.
From January 2007 to August 2011, we enrolled 65 patients (m/f 38/27; mean age 65 years, range 33–83) with advanced NETs having enhanced SSTR expression, treated with PRRT.
The enhanced expression of SSTR was assessed using 68Ga-DOTATOC/DOTATATE PET/CT.
Among all the enrolled patients, 6 of them were excluded from the present analysis since they voluntarily interrupted treatment.
Mean activity/cycle of 2.6 GBq (90Y-DOTATOC/DOTATATE) or 6.0 GBq (177Lu-DOTATOC/DOTATATE) was administrated intravenously (max 9 cycles).
Results.
Complete response (CR) was found in 1/59 (2%) patients, partial remission (PR) in 24/59 (40.5%) patients, stable disease (SD) in 24/59 (40.5%), and progression (PD) in 10/59 (17%) patients.
The overall tumor response rate (CR + PR) was 42.5%.
In 40.5% of patients, the disease could be stabilized.
Overall, 49 out of 59 patients had no tumor progression (83%).
Twelve patients out of 59 (20%) had grade 2-3 hematological side effects including anemia, thrombocytopenia, and leukopenia.
Long-term nephrotoxicity was observed in 3 patients (2 moderate, 1 severe).
Conclusions.
PRRT is a promising perspective for patients with advanced NETs.
American Psychological Association (APA)
Filice, A.& Fraternali, A.& Frasoldati, A.& Asti, M.& Grassi, E.& Massi, L.…[et al.]. 2012. Radiolabeled Somatostatin Analogues Therapy in Advanced Neuroendocrine Tumors : A Single Centre Experience. Journal of Oncology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-463240
Modern Language Association (MLA)
Filice, A.…[et al.]. Radiolabeled Somatostatin Analogues Therapy in Advanced Neuroendocrine Tumors : A Single Centre Experience. Journal of Oncology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-463240
American Medical Association (AMA)
Filice, A.& Fraternali, A.& Frasoldati, A.& Asti, M.& Grassi, E.& Massi, L.…[et al.]. Radiolabeled Somatostatin Analogues Therapy in Advanced Neuroendocrine Tumors : A Single Centre Experience. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-463240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463240