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Immune Privilege as an Intrinsic CNS Property : Astrocytes Protect the CNS against T-Cell-Mediated Neuroinflammation
Joint Authors
Mitchison, N. Avrion
Gimsa, Ulrike
Brunner-Weinzierl, Monika C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Astrocytes have many functions in the central nervous system (CNS).
They support differentiation and homeostasis of neurons and influence synaptic activity.
They are responsible for formation of the blood-brain barrier (BBB) and make up the glia limitans.
Here, we review their contribution to neuroimmune interactions and in particular to those induced by the invasion of activated T cells.
We discuss the mechanisms by which astrocytes regulate pro- and anti-inflammatory aspects of T-cell responses within the CNS.
Depending on the microenvironment, they may become potent antigen-presenting cells for T cells and they may contribute to inflammatory processes.
They are also able to abrogate or reprogram T-cell responses by inducing apoptosis or secreting inhibitory mediators.
We consider apparently contradictory functions of astrocytes in health and disease, particularly in their interaction with lymphocytes, which may either aggravate or suppress neuroinflammation.
American Psychological Association (APA)
Gimsa, Ulrike& Mitchison, N. Avrion& Brunner-Weinzierl, Monika C.. 2013. Immune Privilege as an Intrinsic CNS Property : Astrocytes Protect the CNS against T-Cell-Mediated Neuroinflammation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-463270
Modern Language Association (MLA)
Gimsa, Ulrike…[et al.]. Immune Privilege as an Intrinsic CNS Property : Astrocytes Protect the CNS against T-Cell-Mediated Neuroinflammation. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-463270
American Medical Association (AMA)
Gimsa, Ulrike& Mitchison, N. Avrion& Brunner-Weinzierl, Monika C.. Immune Privilege as an Intrinsic CNS Property : Astrocytes Protect the CNS against T-Cell-Mediated Neuroinflammation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-463270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463270