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Impact of Autologous and Allogeneic Stem Cell Transplantation in Peripheral T-Cell Lymphomas
Author
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Peripheral T/NK-cell lymphomas (PTCLs) are rare malignancies characterized by poor prognosis.
So far, no standard therapy has been established, due to the lack of randomised studies.
High-dose therapy and autologous stem cell transplantation (HDT-autoSCT) have shown good feasibility with low toxicity in retrospective studies.
In relapsing and refractory PTCL several comparison analyses suggest similar efficacy for PTCL when compared with aggressive B-cell lymphoma.
In the upfront setting, prospective data show promising results with a long-lasting overall survival in a relevant subset of patients.
Achieving a complete remission at transplantation seems to be the most important prognostic factor.
Allogeneic stem cell transplantation (alloSCT) has been investigated only as salvage treatment.
Especially when using reduced intensity conditioning regimen, eligible patients seem to benefit from this approach.
To define the role for upfront stem cell transplantation a randomised trial by the German High-Grade Non-Hodgkin Lymphoma Study Group comparing HDT-autoSCT and alloSCT will be initiated this year.
American Psychological Association (APA)
Reimer, Peter. 2010. Impact of Autologous and Allogeneic Stem Cell Transplantation in Peripheral T-Cell Lymphomas. Advances in Hematology،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-463282
Modern Language Association (MLA)
Reimer, Peter. Impact of Autologous and Allogeneic Stem Cell Transplantation in Peripheral T-Cell Lymphomas. Advances in Hematology No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-463282
American Medical Association (AMA)
Reimer, Peter. Impact of Autologous and Allogeneic Stem Cell Transplantation in Peripheral T-Cell Lymphomas. Advances in Hematology. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-463282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463282