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Vitamin D Levels and Lipid Response to Atorvastatin
Joint Authors
del Pino Montes, Javier
Dueňas Laita, Antonio
Abad Manteca, Laura
de Luis, Daniel
Pérez-Castrillón, José Luis
Vega, Gemma
Source
International Journal of Endocrinology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Adequate vitamin D levels are necessary for good vascular health.
1,25-dihydroxycholecalciferol activates CYP3A4, an enzyme of the cytochrome P450 system, which metabolizes atorvastatin to its main metabolites.
The objective of this study was to evaluate the response of cholesterol and triglycerides to atorvastatin according to vitamin D levels.
Sixty-three patients with acute myocardial infarction treated with low and high doses of atorvastatin were included.
Levels of total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol were measured at baseline and at 12 months of follow-up.
Baseline levels of 25-hydroxyvitamin D (25-OHD) were classified as deficient (<30 nmol/L), insufficient (30–50 nmol/L), and normal (>50 nmol/L).
In patients with 25-OHD <30 nmol/L, there were no significant changes in levels of total cholesterol (173±47 mg/dL versus 164±51 mg/dL), triglycerides (151±49 mg/dL versus 177±94 mg/dL), and LDL cholesterol (111±48 mg/dL versus 92 45± mg/dL); whereas patients with insufficient (30–50 nmol/L) and normal vitamin D (>50 nmol/L) had a good response to atorvastatin.
We suggest that vitamin D concentrations >30 nmol/L may be required for atorvastatin to reduce lipid levels in patients with acute myocardial infarction.
American Psychological Association (APA)
Pérez-Castrillón, José Luis& Abad Manteca, Laura& Vega, Gemma& del Pino Montes, Javier& de Luis, Daniel& Dueňas Laita, Antonio. 2009. Vitamin D Levels and Lipid Response to Atorvastatin. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-463293
Modern Language Association (MLA)
Pérez-Castrillón, José Luis…[et al.]. Vitamin D Levels and Lipid Response to Atorvastatin. International Journal of Endocrinology No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-463293
American Medical Association (AMA)
Pérez-Castrillón, José Luis& Abad Manteca, Laura& Vega, Gemma& del Pino Montes, Javier& de Luis, Daniel& Dueňas Laita, Antonio. Vitamin D Levels and Lipid Response to Atorvastatin. International Journal of Endocrinology. 2009. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-463293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463293