Drug Resistance Mechanisms of Mycoplasma pneumoniae to Macrolide Antibiotics
Joint Authors
Jiang, Yue
Shi, Dawei
Xin, Deli
Liu, Xijie
Li, Jing
Chen, Xiaogeng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Throat swabs from children with suspected Mycoplasma pneumoniae (M.
pneumoniae) infection were cultured for the presence of M.
pneumoniae and its species specificity using the 16S rRNA gene.
Seventy-six M.
pneumoniae strains isolated from 580 swabs showed that 70 were erythromycin resistant with minimum inhibitory concentrations (MIC) around 32–512 mg/L.
Fifty M.
pneumoniae strains (46 resistant, 4 sensitive) were tested for sensitivity to tetracycline, ciprofloxacin, and gentamicin.
Tetracycline and ciprofloxacin had some effect, and gentamicin had an effect on the majority of M.
pneumoniae strains.
Domains II and V of the 23S rRNA gene and the ribosomal protein L4 and L22 genes, both of which are considered to be associated with macrolide resistance, were sequenced and the sequences were compared with the corresponding sequences in M129 registered with NCBI and the FH strain.
The 70 resistant strains all showed a 2063 or 2064 site mutation in domain V of the 23S rRNA but no mutations in domain II.
Site mutations of L4 or L22 can be observed in either resistant or sensitive strains, although it is not known whether this is associated with drug resistance.
American Psychological Association (APA)
Liu, Xijie& Jiang, Yue& Chen, Xiaogeng& Li, Jing& Shi, Dawei& Xin, Deli. 2014. Drug Resistance Mechanisms of Mycoplasma pneumoniae to Macrolide Antibiotics. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-463303
Modern Language Association (MLA)
Liu, Xijie…[et al.]. Drug Resistance Mechanisms of Mycoplasma pneumoniae to Macrolide Antibiotics. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-463303
American Medical Association (AMA)
Liu, Xijie& Jiang, Yue& Chen, Xiaogeng& Li, Jing& Shi, Dawei& Xin, Deli. Drug Resistance Mechanisms of Mycoplasma pneumoniae to Macrolide Antibiotics. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-463303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463303