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Cytotoxicity Studies of Novel Combretastatin and Pterostilbene Derivatives
Joint Authors
Ksiazek, Krzysztof
Mikuła-Pietrasik, Justyna
Krawczyk, Hanna
Jakubowska, Joanna
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We synthesised seven 2-aminestilbenes with methoxy substitents in reactions of dinitrostilbenes with sodium azide.
In order to study the positioning of the nitro groups, the optimum structure of obtained stilbenes using the DFT B3LYP/6-311++G(2d,p) method was calculated.
Very interesting aspect of this regioselectivity reaction is the fact that in all substrates and synthetized compounds the nitro groups in position 2 were not coplanar whereas the para-nitro groups were coplanar with respect to the benzene ring.
Due to unique features of stilbene derivatives, such as antitumor agents, we undertook the studies on the biological properties of new stilbene derivatives.
Using five cancer cell lines, we investigated the effects of 2-aminestilbenes with methoxy substitents on cell growth.
American Psychological Association (APA)
Jakubowska, Joanna& Mikuła-Pietrasik, Justyna& Ksiazek, Krzysztof& Krawczyk, Hanna. 2014. Cytotoxicity Studies of Novel Combretastatin and Pterostilbene Derivatives. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-463310
Modern Language Association (MLA)
Jakubowska, Joanna…[et al.]. Cytotoxicity Studies of Novel Combretastatin and Pterostilbene Derivatives. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-463310
American Medical Association (AMA)
Jakubowska, Joanna& Mikuła-Pietrasik, Justyna& Ksiazek, Krzysztof& Krawczyk, Hanna. Cytotoxicity Studies of Novel Combretastatin and Pterostilbene Derivatives. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-463310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463310