![](/images/graphics-bg.png)
Pleiotropic Effects of Thyroid Hormones : Learning from Hypothyroidism
Joint Authors
Franco, Martha
Chávez, Edmundo
Pérez-Méndez, Oscar
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-27
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Hypothyroidism induces several metabolic changes that allow understanding some physiopathological mechanisms.
Under experimental hypothyroid conditions in rats, heart and kidney are protected against oxidative damage induced by ischemia reperfusion.
An increased resistance to opening of the permeability transition pore seems to be at the basis of such protection.
Moreover, glomerular filtration rate of hypothyroid kidney is low as a result of adenosine receptors-induced renal vasoconstriction.
The vascular tone of aorta is also regulated by adenosine in hypothyroid conditions.
In other context, thyroid hormones regulate lipoprotein metabolism.
High plasma level of LDL cholesterol is a common feature in hypothyroidism, due to a low expression of the hepatic LDL receptor.
In contrast, HDL-cholesterol plasma levels are variable in hypothyroidism; several proteins involved in HDL metabolism and structure are expressed at lower levels in experimental hypothyroidism.
Based on the positive influence of thyroid hormones on lipoprotein metabolism, thyromimetic drugs are promising for the treatment of dyslipidemias.
In summary, hypothyroid status has been useful to understand molecular mechanisms involved in ischemia reperfusion, regulation of vascular function and intravascular metabolism of lipoproteins.
American Psychological Association (APA)
Franco, Martha& Chávez, Edmundo& Pérez-Méndez, Oscar. 2011. Pleiotropic Effects of Thyroid Hormones : Learning from Hypothyroidism. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-463324
Modern Language Association (MLA)
Franco, Martha…[et al.]. Pleiotropic Effects of Thyroid Hormones : Learning from Hypothyroidism. Journal of Thyroid Research No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-463324
American Medical Association (AMA)
Franco, Martha& Chávez, Edmundo& Pérez-Méndez, Oscar. Pleiotropic Effects of Thyroid Hormones : Learning from Hypothyroidism. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-463324
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463324