Insulin Receptor Expression and Activity in the Brains of Nondiabetic Sporadic Alzheimer’s Disease Cases
Joint Authors
Haroutunian, Vahram
Pasinetti, Giulio Maria
Knable, Lindsay
Zhao, Rudy
Katsel, Pavel
Yemul, Shrishailam
Ho, Lap
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We investigated the contents of the insulin receptor-beta subunit (IRβ) and [Tyr1162/1163]-phosphorylated IRβ as surrogate indices of total IR content and IR activation in postmortem hippocampal formation brain specimens from nondiabetic sporadic Alzheimer’s disease (AD) cases.
We found no significant changes in the brain contents of total IRβ or [Tyr1162/1163]-phosphorylated IRβ, suggesting normal IR content and activation in the brains of nondiabetic sporadic AD cases.
Moreover, total IRβ and [Tyr1162/1163]-phosphorylated IRβ levels in the hippocampal formation are not correlated with the severity of amyloid or tau-neuropathology.
Exploring the regulation of glycogen synthase kinase 3 (GSK3) α/β, key IR-signaling components, we observed significantly lower levels of total GSK3 α/β in brain specimens from nondiabetic AD cases, suggesting that impaired IR signaling mechanisms might contribute to the onset and/or progression of AD dementia.
Outcomes from our study support the development of insulin-sensitizing therapeutic strategies to stimulate downstream IR signaling in nondiabetic AD cases.
American Psychological Association (APA)
Ho, Lap& Yemul, Shrishailam& Knable, Lindsay& Katsel, Pavel& Zhao, Rudy& Haroutunian, Vahram…[et al.]. 2012. Insulin Receptor Expression and Activity in the Brains of Nondiabetic Sporadic Alzheimer’s Disease Cases. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-463344
Modern Language Association (MLA)
Ho, Lap…[et al.]. Insulin Receptor Expression and Activity in the Brains of Nondiabetic Sporadic Alzheimer’s Disease Cases. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-463344
American Medical Association (AMA)
Ho, Lap& Yemul, Shrishailam& Knable, Lindsay& Katsel, Pavel& Zhao, Rudy& Haroutunian, Vahram…[et al.]. Insulin Receptor Expression and Activity in the Brains of Nondiabetic Sporadic Alzheimer’s Disease Cases. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-463344
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463344