Serology of Lupus Erythematosus : Correlation between Immunopathological Features and Clinical Aspects
Joint Authors
Drosera, Massimo
Parodi, Aurora
Gasparini, Giulia
Cozzani, Emanuele
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the aberrant production of a broad and heterogenous group of autoantibodies.
Even though the presence of autoantibodies in SLE has been known, for more than 60 years, still nowadays a great effort is being made to understand the pathogenetic, diagnostic, and prognostic meaning of such autoantibodies.
Antibodies to ds-DNA are useful for the diagnosis of SLE, to monitor the disease activity, and correlate with renal and central nervous involvements.
Anti-Sm antibodies are highly specific for SLE.
Anti-nucleosome antibodies are an excellent marker for SLE and good predictors of flares in quiescent lupus.
Anti-histone antibodies characterize drug-induced lupus, while anti-SSA/Ro and anti-SSB/La antibodies are associated with neonatal lupus erythematosus and photosensitivity.
Anti-ribosomal P antibodies play a role in neuropsychiatric lupus, but their association with clinical manifestations is still unclear.
Anti-phospholipid antibodies are associated with the anti-phospholipid syndrome, cerebral vascular disease, and neuropsychiatric lupus.
Anti-C1q antibodies amplify glomerular injury, and the elevation of their titers may predict renal flares.
Anti-RNP antibodies are a marker of Sharp’s syndrome but can be found in SLE as well.
Anti-PCNA antibodies are present in 5–10% of SLE patients especially those with arthritis and hypocomplementemia.
American Psychological Association (APA)
Cozzani, Emanuele& Drosera, Massimo& Gasparini, Giulia& Parodi, Aurora. 2014. Serology of Lupus Erythematosus : Correlation between Immunopathological Features and Clinical Aspects. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-463354
Modern Language Association (MLA)
Cozzani, Emanuele…[et al.]. Serology of Lupus Erythematosus : Correlation between Immunopathological Features and Clinical Aspects. Autoimmune Diseases No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-463354
American Medical Association (AMA)
Cozzani, Emanuele& Drosera, Massimo& Gasparini, Giulia& Parodi, Aurora. Serology of Lupus Erythematosus : Correlation between Immunopathological Features and Clinical Aspects. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-463354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463354