Investigation of Estrogen Receptor (ESR1) for Breast Cancer from Traditional Chinese Medicine
Joint Authors
Lee, Wen-Yuan
Chen, Kuen-Bao
Chen, Calvin Yu-Chian
Chan, Yueh-Chiu
Hung, Tzu-Chieh
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Recently, an important topic of breast cancer had been published in 2013.
In this report, estrogen receptor (ESR1) had defined the relation of hormone-cause breast cancer.
The screening of traditional Chinese medicine (TCM) database has found the molecular compounds by simulating molecular docking and molecular dynamics to regulate ESR1.
S-Allylmercaptocysteine and 5-hydroxy-L-tryptophan are selected according to the highest docking score than that of other TCM compounds and Raloxifene (control).
The simulation from molecular dynamics is helpful in analyzing and detecting the protein-ligand interactions.
After a comparing the control and the Apo form, then based on the docking poses, hydrophobic interactions, hydrogen bond and structure variations, this research postulates that S-allylmercaptocysteine may be more appropriate than other compounds for protein-ligand interaction.
American Psychological Association (APA)
Hung, Tzu-Chieh& Lee, Wen-Yuan& Chen, Kuen-Bao& Chan, Yueh-Chiu& Chen, Calvin Yu-Chian. 2014. Investigation of Estrogen Receptor (ESR1) for Breast Cancer from Traditional Chinese Medicine. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-463370
Modern Language Association (MLA)
Hung, Tzu-Chieh…[et al.]. Investigation of Estrogen Receptor (ESR1) for Breast Cancer from Traditional Chinese Medicine. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-463370
American Medical Association (AMA)
Hung, Tzu-Chieh& Lee, Wen-Yuan& Chen, Kuen-Bao& Chan, Yueh-Chiu& Chen, Calvin Yu-Chian. Investigation of Estrogen Receptor (ESR1) for Breast Cancer from Traditional Chinese Medicine. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-463370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463370