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Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate Cancer
Joint Authors
Boller, Annkathrin
Jünemann, Klaus-Peter
Osmonov, Daniar K.
Heimann, Diana
Janssen, Isa
Aksenov, Alexey V.
Kalz, Almut
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Treatment of patients with a biochemical recurrence (BCR) of prostate cancer (PCa) is generally difficult and without valid treatment options.
Since 2004 we have been developing therapeutic possibilities for these patients.
Methods.
We retrospectively analyzed a cohort of 41 patients with a BCR of PCa and a mean followup of 40.3±20.8 months.
Group 1 (n=10): salvage radical prostatectomy (sRP) with SePLND (salvage extended pelvic lymph nodes dissection) (initial treatment: combined brachytherapy).
Group 2 (n=22): SePLND (initial treatment: radical prostatectomy (RP)).
Group 3 (n=9): SePLND (initial treatment: RP and adjuvant radiation therapy (RT)).
We observed PSA, PSA-velocity, localization of LNs and LNs+, BCR-free period, and BR (biochemical response).
Results.
Group 1: 60% with BCR-freedom (mean 27.2 months).
Group 2: 63.6% with BCR-freedom (mean 17.5 months).
Group 3: 33.3% with BCR-freedom (mean 17.6 months).
In total, BCR-freedom was observed in 23 of 41 patients (56.1%) after salvage surgery.
75.6% of all patients showed a BR.
765 LNs were removed and 14.8% of these were LN+.
Conclusions.
The BCR-free period and BR are comparable in all three groups.
Sensibility to ADT can be reestablished and prolonged as a result of SePLND.
Multicenter studies are needed for a reliable output.
American Psychological Association (APA)
Osmonov, Daniar K.& Aksenov, Alexey V.& Boller, Annkathrin& Kalz, Almut& Heimann, Diana& Janssen, Isa…[et al.]. 2014. Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate Cancer. Advances in Urology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-463383
Modern Language Association (MLA)
Osmonov, Daniar K.…[et al.]. Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate Cancer. Advances in Urology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-463383
American Medical Association (AMA)
Osmonov, Daniar K.& Aksenov, Alexey V.& Boller, Annkathrin& Kalz, Almut& Heimann, Diana& Janssen, Isa…[et al.]. Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate Cancer. Advances in Urology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-463383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463383