Pleiotropic Cellular Functions of PARP1 in Longevity and Aging : Genome Maintenance Meets Inflammation
Joint Authors
Bürkle, Alexander
Mangerich, Aswin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-19
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Aging is a multifactorial process that depends on diverse molecular and cellular mechanisms, such as genome maintenance and inflammation.
The nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP1), which catalyzes the synthesis of the biopolymer poly(ADP-ribose), exhibits an essential role in both processes.
On the one hand, PARP1 serves as a genomic caretaker as it participates in chromatin remodelling, DNA repair, telomere maintenance, resolution of replicative stress, and cell cycle control.
On the other hand, PARP1 acts as a mediator of inflammation due to its function as a regulator of NF-κB and other transcription factors and its potential to induce cell death.
Consequently, PARP1 represents an interesting player in several aging mechanisms and is discussed as a longevity assurance factor on the one hand and an aging-promoting factor on the other hand.
Here, we review the molecular mechanisms underlying the various roles of PARP1 in longevity and aging with special emphasis on cellular studies and we briefly discuss the results in the context of in vivo studies in mice and humans.
American Psychological Association (APA)
Mangerich, Aswin& Bürkle, Alexander. 2012. Pleiotropic Cellular Functions of PARP1 in Longevity and Aging : Genome Maintenance Meets Inflammation. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-463385
Modern Language Association (MLA)
Mangerich, Aswin& Bürkle, Alexander. Pleiotropic Cellular Functions of PARP1 in Longevity and Aging : Genome Maintenance Meets Inflammation. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-19.
https://search.emarefa.net/detail/BIM-463385
American Medical Association (AMA)
Mangerich, Aswin& Bürkle, Alexander. Pleiotropic Cellular Functions of PARP1 in Longevity and Aging : Genome Maintenance Meets Inflammation. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-463385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463385