Antioxidants in Kidney Diseases : The Impact of Bardoxolone Methyl
Joint Authors
Arduán, Alberto Ortiz
Egido, Jesus
Rojas-Rivera, Jorge
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Drugs targeting the renin-angiotensin-aldosterone system (RAAS) are the mainstay of therapy to retard the progression of proteinuric chronic kidney disease (CKD) such as diabetic nephropathy.
However, diabetic nephropathy is still the first cause of end-stage renal disease.
New drugs targeted to the pathogenesis and mechanisms of progression of these diseases beyond RAAS inhibition are needed.
There is solid experimental evidence of a key role of oxidative stress and its interrelation with inflammation on renal damage.
However, randomized and well-powered trials on these agents in CKD are scarce.
We now review the biological bases of oxidative stress and its role in kidney diseases, with focus on diabetic nephropathy, as well as the role of the Keap1-Nrf2 pathway and recent clinical trials targeting this pathway with bardoxolone methyl.
American Psychological Association (APA)
Rojas-Rivera, Jorge& Arduán, Alberto Ortiz& Egido, Jesus. 2012. Antioxidants in Kidney Diseases : The Impact of Bardoxolone Methyl. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-463394
Modern Language Association (MLA)
Rojas-Rivera, Jorge…[et al.]. Antioxidants in Kidney Diseases : The Impact of Bardoxolone Methyl. International Journal of Nephrology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-463394
American Medical Association (AMA)
Rojas-Rivera, Jorge& Arduán, Alberto Ortiz& Egido, Jesus. Antioxidants in Kidney Diseases : The Impact of Bardoxolone Methyl. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-463394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463394