Nanosized Mesoporous Bioactive GlassPoly(lactic-co-glycolic Acid) Composite-Coated CaSiO3 Scaffolds with Multifunctional Properties for Bone Tissue Engineering
Joint Authors
Wu, Chengtie
Shi, Mengchao
Zhai, Dong
Zhao, Lang
Chang, Jiang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
It is of great importance to prepare multifunctional scaffolds combining good mechanical strength, bioactivity, and drug delivery ability for bone tissue engineering.
In this study, nanosized mesoporous bioglass/poly(lactic-co-glycolic acid) composite-coated calcium silicate scaffolds, named NMBG-PLGA/CS, were successfully prepared.
The morphology and structure of the prepared scaffolds were characterized by scanning electron microscopy and X-ray diffraction.
The effects of NMBG on the apatite mineralization activity and mechanical strength of the scaffolds and the attachment, proliferation, and alkaline phosphatase activity of MC3T3 cells as well as drug ibuprofen delivery properties were systematically studied.
Compared to pure CS scaffolds and PLGA/CS scaffolds, the prepared NMBG-PLGA/CS scaffolds had greatly improved apatite mineralization activity in simulated body fluids, much higher mechanical property, and supported the attachment of MC3T3 cells and enhanced the cell proliferation and ALP activity.
Furthermore, the prepared NMBG-PLGA/CS scaffolds could be used for delivering ibuprofen with a sustained release profile.
Our study suggests that the prepared NMBG-PLGA/CS scaffolds have improved physicochemical, biological, and drug-delivery property as compared to conventional CS scaffolds, indicating that the multifunctional property of the prepared scaffolds for the potential application of bone tissue engineering.
American Psychological Association (APA)
Shi, Mengchao& Zhai, Dong& Zhao, Lang& Wu, Chengtie& Chang, Jiang. 2014. Nanosized Mesoporous Bioactive GlassPoly(lactic-co-glycolic Acid) Composite-Coated CaSiO3 Scaffolds with Multifunctional Properties for Bone Tissue Engineering. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-463416
Modern Language Association (MLA)
Shi, Mengchao…[et al.]. Nanosized Mesoporous Bioactive GlassPoly(lactic-co-glycolic Acid) Composite-Coated CaSiO3 Scaffolds with Multifunctional Properties for Bone Tissue Engineering. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-463416
American Medical Association (AMA)
Shi, Mengchao& Zhai, Dong& Zhao, Lang& Wu, Chengtie& Chang, Jiang. Nanosized Mesoporous Bioactive GlassPoly(lactic-co-glycolic Acid) Composite-Coated CaSiO3 Scaffolds with Multifunctional Properties for Bone Tissue Engineering. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-463416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463416