Protective Effects of Luteolin on Diabetic Nephropathy in STZ-Induced Diabetic Rats
Joint Authors
Lu, Xiao Hua
Li, Wei
Zhang, Cui
Zhao, Xue
Wang, Guo Guang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetic nephropathy is a long-term complication of diabetic mellitus.
Many experimental evidences suggest that persistent hyperglycaemia generates intracellular reactive oxygen species (ROS) and upregulates transforming growth factor-b1 and extracellular matrix expression in mesangial and tubular epithelial cells, which is involved of free radicals in the pathogenesis of diabetes and more importantly in the development of diabetic complications.
Antioxidants effectively inhibit high-glucose- and H2O2-induced transforming growth factor-b1 and fibronectin upregulation, thus providing evidence that ROS play an important role in high glucose-induced renal injury.
The flavonoid luteolin has been shown to possess direct antioxidant activity, therefore we hypothesize that it may be useful in treatment of many chronic disease associated with oxidative stress, such as diabetic nephropathy via its antioxidant properties.
Our results suggested that protection against development of diabetic nephropathy by luteolin treatment involved changes in superoxide dismutase (SOD) activity, the malondialdehyde (MDA) content and expression of Heme Oxygenase-1 (HO-1) protein.
American Psychological Association (APA)
Wang, Guo Guang& Lu, Xiao Hua& Li, Wei& Zhao, Xue& Zhang, Cui. 2011. Protective Effects of Luteolin on Diabetic Nephropathy in STZ-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-463428
Modern Language Association (MLA)
Wang, Guo Guang…[et al.]. Protective Effects of Luteolin on Diabetic Nephropathy in STZ-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-463428
American Medical Association (AMA)
Wang, Guo Guang& Lu, Xiao Hua& Li, Wei& Zhao, Xue& Zhang, Cui. Protective Effects of Luteolin on Diabetic Nephropathy in STZ-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-463428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463428