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Peroxynitrite and Peroxiredoxin in the Pathogenesis of Experimental Amebic Liver Abscess
Joint Authors
Campos-Rodriguez, Rafael
Abarca-Rojano, Edgar
Jarillo-Luna, Rosa Adriana
Larsen, Bruce Allan
Gutierrez-Meza, Manuel
Pacheco-Yepez, Judith
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-14
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The molecular mechanisms by which Entamoeba histolytica causes amebic liver abscess (ALA) are still not fully understood.
Amebic mechanisms of adherence and cytotoxic activity are pivotal for amebic survival but apparently do not directly cause liver abscess.
Abundant evidence indicates that chronic inflammation (resulting from an inadequate immune response) is probably the main cause of ALA.
Reports referring to inflammatory mechanisms of liver damage mention a repertoire of toxic molecules by the immune response (especially nitric oxide and reactive oxygen intermediates) and cytotoxic substances released by neutrophils and macrophages after being lysed by amoebas (e.g., defensins, complement, and proteases).
Nevertheless, recent evidence downplays these mechanisms in abscess formation and emphasizes the importance of peroxynitrite (ONOO−).
It seems that the defense mechanism of amoebas against ONOO−, namely, the amebic thioredoxin system (including peroxiredoxin), is superior to that of mammals.
The aim of the present text is to define the importance of ONOO− as the main agent of liver abscess formation during amebic invasion, and to explain the superior capacity of amoebas to defend themselves against this toxic agent through the peroxiredoxin and thioredoxin system.
American Psychological Association (APA)
Pacheco-Yepez, Judith& Jarillo-Luna, Rosa Adriana& Gutierrez-Meza, Manuel& Abarca-Rojano, Edgar& Larsen, Bruce Allan& Campos-Rodriguez, Rafael. 2014. Peroxynitrite and Peroxiredoxin in the Pathogenesis of Experimental Amebic Liver Abscess. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-463511
Modern Language Association (MLA)
Pacheco-Yepez, Judith…[et al.]. Peroxynitrite and Peroxiredoxin in the Pathogenesis of Experimental Amebic Liver Abscess. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-463511
American Medical Association (AMA)
Pacheco-Yepez, Judith& Jarillo-Luna, Rosa Adriana& Gutierrez-Meza, Manuel& Abarca-Rojano, Edgar& Larsen, Bruce Allan& Campos-Rodriguez, Rafael. Peroxynitrite and Peroxiredoxin in the Pathogenesis of Experimental Amebic Liver Abscess. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-463511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463511