Protection of Coronary Endothelial Function during Cardiac Surgery : Potential of Targeting Endothelial Ion Channels in Cardioprotection
Joint Authors
Yu, Cheuk-Man
Underwood, Malcolm John
He, Guo-Wei
Yang, Qin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Vascular endothelium plays a critical role in the control of blood flow by producing vasoactive factors to regulate vascular tone.
Ion channels, in particular, K+ channels and Ca2+-permeable channels in endothelial cells, are essential to the production and function of endothelium-derived vasoactive factors.
Impairment of coronary endothelial function occurs in open heart surgery that may result in reduction of coronary blood flow and thus in an inadequate myocardial perfusion.
Hyperkalemic exposure and concurrent ischemia-reperfusion during cardioplegic intervention compromise NO and EDHF-mediated function and the impairment involves alterations of K+ channels, that is, KATP and KCa, and Ca2+-permeable TRP channels in endothelial cells.
Pharmacological modulation of these channels during ischemia-reperfusion and hyperkalemic exposure show promising results on the preservation of NO and EDHF-mediated endothelial function, which suggests the potential of targeting endothelial K+ and TRP channels for myocardial protection during cardiac surgery.
American Psychological Association (APA)
Yang, Qin& Yu, Cheuk-Man& He, Guo-Wei& Underwood, Malcolm John. 2014. Protection of Coronary Endothelial Function during Cardiac Surgery : Potential of Targeting Endothelial Ion Channels in Cardioprotection. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-463527
Modern Language Association (MLA)
Yang, Qin…[et al.]. Protection of Coronary Endothelial Function during Cardiac Surgery : Potential of Targeting Endothelial Ion Channels in Cardioprotection. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-463527
American Medical Association (AMA)
Yang, Qin& Yu, Cheuk-Man& He, Guo-Wei& Underwood, Malcolm John. Protection of Coronary Endothelial Function during Cardiac Surgery : Potential of Targeting Endothelial Ion Channels in Cardioprotection. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-463527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463527