A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease
Joint Authors
Blanca Ramírez, Marian
Hilfiker, Sabine
Fdez, Elena
Gómez-Suaga, Patricia
Source
Advances in Acoustics and Vibration
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Parkinson's disease is a debilitating neurodegenerative disorder, and its molecular etiopathogenesis remains poorly understood.
The discovery of monogenic forms has significantly advanced our understanding of the molecular mechanisms underlying PD, as it allows generation of cellular and animal models carrying the mutant gene to define pathological pathways.
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause dominantly inherited PD, and variations increase risk, indicating that LRRK2 is an important player in both genetic and sporadic forms of the disease.
G2019S, the most prominent pathogenic mutation, maps to the kinase domain and enhances enzymatic activity of LRRK2, which in turn seems to correlate with cytotoxicity.
Since kinases are druggable targets, this has raised great hopes that disease-modifying therapies may be developed around modifying LRRK2 enzymatic activity.
Apart from cytotoxicity, changes in autophagy have been consistently reported in the context of G2019S mutant LRRK2.
Here, we will discuss current knowledge about mechanism(s) by which mutant LRRK2 may regulate autophagy, which highlights additional putative therapeutic targets.
American Psychological Association (APA)
Gómez-Suaga, Patricia& Fdez, Elena& Blanca Ramírez, Marian& Hilfiker, Sabine. 2012. A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease. Advances in Acoustics and Vibration،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463536
Modern Language Association (MLA)
Gómez-Suaga, Patricia…[et al.]. A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease. Advances in Acoustics and Vibration No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-463536
American Medical Association (AMA)
Gómez-Suaga, Patricia& Fdez, Elena& Blanca Ramírez, Marian& Hilfiker, Sabine. A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease. Advances in Acoustics and Vibration. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463536