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Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap : A Case Report
Joint Authors
Cirillo, Giovanni
Sagnelli, Anna
Femiano, Cinzia
Trojsi, Francesca
Monsurrò, Maria Rosaria
Izzo, Francesco
Piccirillo, Giovanni
Tedeschi, Gioacchino
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The concurrence of amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) is extremely rare.
We reported the case of a 33-year-old woman with a past history of paresthesias at the right hand, who developed progressive quadriparesis with muscular atrophy of limbs and, finally, bulbar signs and dyspnea.
Clinical and neurophysiologic investigations revealed upper and lower motor neuron signs in the bulbar region and extremities, suggesting the diagnosis of ALS.
Moreover, magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) analysis demonstrated 3 periventricular and juxtacortical lesions, hyperintense in T2 and FLAIR sequences, and 3 liquoral immunoglobulin G (IgG) oligoclonal bands, consistent with diagnosis of primary progressive MS (PPMS).
This unusual overlap of ALS and MS leads to the discussion of a hypothetical common pathological process of immunological dysfunction in these two disorders, although the role of immune response in ALS remains ambivalent and unclear.
American Psychological Association (APA)
Trojsi, Francesca& Sagnelli, Anna& Cirillo, Giovanni& Piccirillo, Giovanni& Femiano, Cinzia& Izzo, Francesco…[et al.]. 2012. Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap : A Case Report. Case Reports in Medicine،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-463561
Modern Language Association (MLA)
Trojsi, Francesca…[et al.]. Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap : A Case Report. Case Reports in Medicine No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-463561
American Medical Association (AMA)
Trojsi, Francesca& Sagnelli, Anna& Cirillo, Giovanni& Piccirillo, Giovanni& Femiano, Cinzia& Izzo, Francesco…[et al.]. Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap : A Case Report. Case Reports in Medicine. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-463561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463561