Parafibromin as a Diagnostic Instrument for Parathyroid Carcinoma-Lone Ranger or Part of the Posse?
Joint Authors
Höög, Anders
Juhlin, C. Christofer
Source
International Journal of Endocrinology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The diagnosis of parathyroid carcinoma requires an invasive growth pattern or metastases detected at histopathological examination; unfortunately, not all carcinomas exhibit visible malignant properties at the initial assessment.
Therefore, immunohistochemical markers have been sought for the recognition of parathyroid malignancy.
In 2003, the Hyperparathyroidism 2 (HRPT2) gene was found mutated in the majority of sporadic parathyroid carcinomas investigated, and studies regarding the protein product parafibromin proposed loss of nuclear parafibromin as a highly sensitive marker for the detection of parathyroid carcinoma.
Recent studies have not fully reproduced these findings, as subsets of carcinomas display positive parafibromin immunoreactivity, and fractions of adenomas demonstrate absent expression.
Overall, parafibromin is a marker of value to the endocrine pathologist, but it cannot be recommended as a sole indicator of parathyroid carcinoma.
Additional markers such as protein gene product 9.5 (PGP9.5) and adenomatous polyposis coli (APC) could complement parafibromin when assessing malignant potential of parathyroid tumours.
American Psychological Association (APA)
Juhlin, C. Christofer& Höög, Anders. 2010. Parafibromin as a Diagnostic Instrument for Parathyroid Carcinoma-Lone Ranger or Part of the Posse?. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-463597
Modern Language Association (MLA)
Juhlin, C. Christofer& Höög, Anders. Parafibromin as a Diagnostic Instrument for Parathyroid Carcinoma-Lone Ranger or Part of the Posse?. International Journal of Endocrinology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-463597
American Medical Association (AMA)
Juhlin, C. Christofer& Höög, Anders. Parafibromin as a Diagnostic Instrument for Parathyroid Carcinoma-Lone Ranger or Part of the Posse?. International Journal of Endocrinology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-463597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463597