New Insights in the Amyloid-Beta Interaction with Mitochondria
Joint Authors
Spuch, Carlos
Navarro, Carmen
Ortolano, Saida
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Biochemical and morphological alterations of mitochondria may play an important role in the pathogenesis of Alzheimer’s disease (AD).
Particularly, mitochondrial dysfunction is a hallmark of amyloid-beta-induced neuronal toxicity in Alzheimer’s disease.
The recent emphasis on the intracellular biology of amyloid-beta and its precursor protein (APP) has led researchers to consider the possibility that mitochondria-associated and mitochondrial amyloid-beta may directly cause neurotoxicity.
Both proteins are known to localize to mitochondrial membranes, block the transport of nuclear-encoded mitochondrial proteins to mitochondria, interact with mitochondrial proteins, disrupt the electron transport chain, increase reactive oxygen species production, cause mitochondrial damage, and prevent neurons from functioning normally.
In this paper, we will outline current knowledge of the intracellular localization of amyloid-beta.
Moreover, we summarize evidence from AD postmortem brain as well as animal AD models showing that amyloid-beta triggers mitochondrial dysfunction through a number of pathways such as impairment of oxidative phosphorylation, elevation of reactive oxygen species production, alteration of mitochondrial dynamics, and interaction with mitochondrial proteins.
Thus, this paper supports the Alzheimer cascade mitochondrial hypothesis such as the most important early events in this disease, and probably one of the future strategies on the therapy of this neurodegenerative disease.
American Psychological Association (APA)
Spuch, Carlos& Ortolano, Saida& Navarro, Carmen. 2012. New Insights in the Amyloid-Beta Interaction with Mitochondria. Journal of Aging Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463598
Modern Language Association (MLA)
Spuch, Carlos…[et al.]. New Insights in the Amyloid-Beta Interaction with Mitochondria. Journal of Aging Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-463598
American Medical Association (AMA)
Spuch, Carlos& Ortolano, Saida& Navarro, Carmen. New Insights in the Amyloid-Beta Interaction with Mitochondria. Journal of Aging Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463598
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463598