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Hepatic Dysfunction in Hospitalized Patients with Acute Thyrotoxicosis : A Decade of Experience
Joint Authors
Barsness, Gregory W.
Dean, Diana S.
Elias, Richard M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Thyroid disease is a common condition, and thyroid hormone excess or deficiency is known to have wide-ranging effects on a variety of organ systems.
Our objective is to describe the magnitude, biochemical features, and clinical characteristics of hepatic abnormalities in patients with acute thyrotoxicosis.
We performed a retrospective review of all patients admitted to our institution between January 1, 1998 and December 31, 2008 with a discharge diagnosis of acute thyrotoxicosis excluding iatrogenic causes.
The records of these patients were reviewed and data extracted regarding demographic, biochemical, and clinical data particularly relevant to liver function.
Fourteen patients were identified of which eleven had liver studies performed.
The majority (90.9%) had Graves disease.
Nine of eleven patients (81.8%) had some degree of hepatic abnormality.
Seven patients (63.6%) had an elevation in one or both transaminases, and two (18.2%) had isolated synthetic dysfunction as manifested as an elevated INR and/or decreased albumin without transaminitis.
The mean magnitude of deviation from the normal range was greater in the transaminases as compared to bilirubin, INR, or albumin.
Definitive treatment was radioiodine ablation in six cases (54.5%) and surgical thyroidectomy in two cases (18.2%).
Noniatrogenic acute thyrotoxicosis requiring hospitalization is a rare condition which is most frequently caused by Graves disease.
The majority of patients have disordered liver tests of a highly variable nature, making the recognition of this association important in the care of patients presenting with acute thyrotoxicosis.
American Psychological Association (APA)
Elias, Richard M.& Dean, Diana S.& Barsness, Gregory W.. 2012. Hepatic Dysfunction in Hospitalized Patients with Acute Thyrotoxicosis : A Decade of Experience. ISRN Endocrinology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-463608
Modern Language Association (MLA)
Elias, Richard M.…[et al.]. Hepatic Dysfunction in Hospitalized Patients with Acute Thyrotoxicosis : A Decade of Experience. ISRN Endocrinology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-463608
American Medical Association (AMA)
Elias, Richard M.& Dean, Diana S.& Barsness, Gregory W.. Hepatic Dysfunction in Hospitalized Patients with Acute Thyrotoxicosis : A Decade of Experience. ISRN Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-463608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463608