Defective Osteogenic Differentiation in the Development of Osteosarcoma
Joint Authors
Hu, Ning
Luu, Hue H.
Gao, Yanhong
Shi, Qiong
Luo, Jinyong
Gao, Jian-Li
Su, Yuxi
Bi, Yang
Haydon, Rex C.
Liu, Xing
Huang, Enyi
Kim, Stephanie H.
Li, Mi
Rames, Richard
Tang, Ni
Luther, Gaurav
Yang, Ke
Zuo, Guowei
Teven, Chad
Luo, Qing
Zhu, Gaohui
Wang, Linyuan
He, Bai-Cheng
He, Tong-Chuan
Chen, Liang
Luo, Xiaoji
Wagner, Eric R.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance.
It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt.
Although certain genetic conditions and alterations increase the risk of developing OS, the molecular pathogenesis is poorly understood.
Recently, defects in differentiation have been linked to cancers, as they are associated with high cell proliferation.
Treatments overcoming these defects enable terminal differentiation and subsequent tumor inhibition.
OS development may be associated with defects in osteogenic differentiation.
While early regulators of osteogenesis are unable to bypass these defects, late osteogenic regulators, including Runx2 and Osterix, are able to overcome some of the defects and inhibit tumor propagation through promoting osteogenic differentiation.
Further understanding of the relationship between defects in osteogenic differentiation and tumor development holds tremendous potential in treating OS.
American Psychological Association (APA)
Wagner, Eric R.& Luther, Gaurav& Zhu, Gaohui& Luo, Qing& Shi, Qiong& Kim, Stephanie H.…[et al.]. 2011. Defective Osteogenic Differentiation in the Development of Osteosarcoma. Sarcoma،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-463619
Modern Language Association (MLA)
Wagner, Eric R.…[et al.]. Defective Osteogenic Differentiation in the Development of Osteosarcoma. Sarcoma No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-463619
American Medical Association (AMA)
Wagner, Eric R.& Luther, Gaurav& Zhu, Gaohui& Luo, Qing& Shi, Qiong& Kim, Stephanie H.…[et al.]. Defective Osteogenic Differentiation in the Development of Osteosarcoma. Sarcoma. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-463619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463619