Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21
Joint Authors
Hu, Yiping
Cheng, Wenxiang
Li, Jinchao
Zhang, Peng
Liu, Ruoxi
Yue, Ye
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This research was performed to observe the effect of GTS-21 on Collagen Induced Arthritis (CIA).
CIA model was used and after the onset of arthritis, the rats were divided into three groups based on their clinical symptoms score.
Two groups were intraperitoneally (IP) injected daily with GTS-21 (1 mg/kg, 2.5 mg/kg) for a week, whereas phosphate buffered saline (PBS) was used for the control group.
Cytokine titers, radiological, and histological examinations were performed at different time points after treatment with GTS-21.
Compared with those of the control, the levels of TNF-α, IL-1, and IL-6 in the serum were significantly reduced after GTS-21 management.
In addition, radiological results show that bone degradation was inhibited as well.
Moreover, the hematoxylin and eosin (H&E) staining indicated that the histological score was significantly alleviated in the therapeutic group.
Tartrate-resistant acid phosphatase (TRAP) stain-positive cells were also detected in the destruction of the articular cartilage, which was significantly reduced compared with the control group.
This study provides the first evidence on the effect of GTS-21 as a potential treatment for RA.
American Psychological Association (APA)
Hu, Yiping& Liu, Ruoxi& Li, Jinchao& Yue, Ye& Cheng, Wenxiang& Zhang, Peng. 2014. Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-463686
Modern Language Association (MLA)
Hu, Yiping…[et al.]. Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-463686
American Medical Association (AMA)
Hu, Yiping& Liu, Ruoxi& Li, Jinchao& Yue, Ye& Cheng, Wenxiang& Zhang, Peng. Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-463686
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463686