A Review of the Combination of Experimental Measurements and Fibril-Reinforced Modeling for Investigation of Articular Cartilage and Chondrocyte Response to Loading
Joint Authors
Isaksson, Hanna
Wilson, Wouter
Korhonen, Rami K.
Julkunen, Petro
Jurvelin, Jukka S.
Herzog, Walter
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-08
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
The function of articular cartilage depends on its structure and composition, sensitively impaired in disease (e.g.
osteoarthritis, OA).
Responses of chondrocytes to tissue loading are modulated by the structure.
Altered cell responses as an effect of OA may regulate cartilage mechanotransduction and cell biosynthesis.
To be able to evaluate cell responses and factors affecting the onset and progression of OA, local tissue and cell stresses and strains in cartilage need to be characterized.
This is extremely challenging with the presently available experimental techniques and therefore computational modeling is required.
Modern models of articular cartilage are inhomogeneous and anisotropic, and they include many aspects of the real tissue structure and composition.
In this paper, we provide an overview of the computational applications that have been developed for modeling the mechanics of articular cartilage at the tissue and cellular level.
We concentrate on the use of fibril-reinforced models of cartilage.
Furthermore, we introduce practical considerations for modeling applications, including also experimental tests that can be combined with the modeling approach.
At the end, we discuss the prospects for patient-specific models when aiming to use finite element modeling analysis and evaluation of articular cartilage function, cellular responses, failure points, OA progression, and rehabilitation.
American Psychological Association (APA)
Julkunen, Petro& Wilson, Wouter& Isaksson, Hanna& Jurvelin, Jukka S.& Herzog, Walter& Korhonen, Rami K.. 2013. A Review of the Combination of Experimental Measurements and Fibril-Reinforced Modeling for Investigation of Articular Cartilage and Chondrocyte Response to Loading. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-23.
https://search.emarefa.net/detail/BIM-463709
Modern Language Association (MLA)
Julkunen, Petro…[et al.]. A Review of the Combination of Experimental Measurements and Fibril-Reinforced Modeling for Investigation of Articular Cartilage and Chondrocyte Response to Loading. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-23.
https://search.emarefa.net/detail/BIM-463709
American Medical Association (AMA)
Julkunen, Petro& Wilson, Wouter& Isaksson, Hanna& Jurvelin, Jukka S.& Herzog, Walter& Korhonen, Rami K.. A Review of the Combination of Experimental Measurements and Fibril-Reinforced Modeling for Investigation of Articular Cartilage and Chondrocyte Response to Loading. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-23.
https://search.emarefa.net/detail/BIM-463709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463709