Cell Death Pathways as Therapeutic Targets in Rhabdomyosarcoma
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Resistance of rhabdomyosarcoma to current therapies remains one of the key issues in pediatric oncology.
Since the success of most cytotoxic therapies in the treatment of cancer, for example, chemotherapy, depends on intact signaling pathways that mediate programmed cell death (apoptosis), defects in apoptosis programs in cancer cells may result in resistance.
Evasion of apoptosis in rhabdomyosarcoma may be caused by defects in the expression or function of critical mediators of apoptosis or in aberrant expression of antiapoptotic proteins.
Therefore, the identification of the molecular mechanisms that confer primary or acquired resistance to apoptosis in rhabdomyosarcoma presents a critical step for the rational development of molecular targeted drugs.
This approach will likely open novel perspectives for the treatment of rhabdomyosarcoma.
American Psychological Association (APA)
Fulda, Simone. 2012. Cell Death Pathways as Therapeutic Targets in Rhabdomyosarcoma. Sarcoma،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-463714
Modern Language Association (MLA)
Fulda, Simone. Cell Death Pathways as Therapeutic Targets in Rhabdomyosarcoma. Sarcoma No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-463714
American Medical Association (AMA)
Fulda, Simone. Cell Death Pathways as Therapeutic Targets in Rhabdomyosarcoma. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-463714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463714