Melatonin in Mitochondrial Dysfunction and Related Disorders
Joint Authors
Brown, Gregory M.
Srinivasan, Venkatramanujam
Pandi-Perumal, Seithikurippu R.
Cardinali, Daniel P.
Warren Spence, D.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-04
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Mitochondrial dysfunction is considered one of the major causative factors in the aging process, ischemia/reperfusion (I/R), septic shock, and neurodegenerative disorders like Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD).
Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO) synthase activity, enhanced NO production, decreased respiratory complex activity, impaired electron transport system, and opening of mitochondrial permeability transition pore all have been suggested as factors responsible for impaired mitochondrial function.
Melatonin, the major hormone of the pineal gland, also acts as an antioxidant and as a regulator of mitochondrial bioenergetic function.
Both in vitro and in vivo, melatonin was effective for preventing oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of PD, AD, and HD.
In addition, melatonin is known to retard aging and to inhibit the lethal effects of septic shock or I/R lesions by maintaining respiratory complex activities, electron transport chain, and ATP production in mitochondria.
Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other antioxidants.
Melatonin has thus emerged as a major potential therapeutic tool for treating neurodegenerative disorders such as PD or AD, and for preventing the lethal effects of septic shock or I/R.
American Psychological Association (APA)
Srinivasan, Venkatramanujam& Warren Spence, D.& Pandi-Perumal, Seithikurippu R.& Brown, Gregory M.& Cardinali, Daniel P.. 2011. Melatonin in Mitochondrial Dysfunction and Related Disorders. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-463725
Modern Language Association (MLA)
Srinivasan, Venkatramanujam…[et al.]. Melatonin in Mitochondrial Dysfunction and Related Disorders. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-463725
American Medical Association (AMA)
Srinivasan, Venkatramanujam& Warren Spence, D.& Pandi-Perumal, Seithikurippu R.& Brown, Gregory M.& Cardinali, Daniel P.. Melatonin in Mitochondrial Dysfunction and Related Disorders. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-463725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463725