Peptide Mimicrying Between SARS Coronavirus Spike Protein and Human Proteins Reacts with SARS Patient Serum
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Molecular mimicry, defined as similar structures shared by molecules from dissimilar genes or proteins, is a general strategy used by pathogens to infect host cells.
Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV).
The spike (S) protein of SARS-CoV plays an important role in the virus entry into a cell.
In this study, eleven synthetic peptides from the S protein were selected based on its sequence homology with human proteins.
Two of the peptides D07 (residues 927–937) and D08 (residues 942–951) were recognized by the sera of SARS patients.
Murine hyperimmune sera against these peptides bound to proteins of human lung epithelial cells A549.
Another peptide D10 (residues 490–502) stimulated A549 to proliferate and secrete IL-8.
The present results suggest that the selected S protein regions, which share sequence homology with human proteins, may play important roles in SARS-CoV infection.
American Psychological Association (APA)
2008. Peptide Mimicrying Between SARS Coronavirus Spike Protein and Human Proteins Reacts with SARS Patient Serum. Journal of Biomedicine and Biotechnology،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-463738
Modern Language Association (MLA)
Peptide Mimicrying Between SARS Coronavirus Spike Protein and Human Proteins Reacts with SARS Patient Serum. Journal of Biomedicine and Biotechnology No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-463738
American Medical Association (AMA)
Peptide Mimicrying Between SARS Coronavirus Spike Protein and Human Proteins Reacts with SARS Patient Serum. Journal of Biomedicine and Biotechnology. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-463738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463738