Potential Protection of Coeloglossum viride var. Bracteatum Extract against Oxidative Stress in Rat Cortical Neurons
Joint Authors
Qin, Xiao-Yan
Guo, Zhe
Pan, Rui-Yuan
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study explored the neuroprotective effect of Coeloglossum viride var.
bracteatum extract (CE) against oxidative stress in rat cortical neurons.
The results demonstrated that administration of CE inhibited hydrogen peroxide-induced neurotoxicity tested by MTT, LDH release, and TUNEL assays.
We further found that CE inhibited the activation of caspase-3 (Csp3) induced by hydrogen peroxide.
Moreover, CE was found to reverse the hydrogen peroxide-induced downregulation of active AKT and Bcl-2.
We then showed that the neuroprotective effect of CE was blocked by adding the AKT inhibitor, Ly294002.
Thus, our data strongly indicated that CE played a neuroprotective role against oxidative stress-induced neurotoxicity.
American Psychological Association (APA)
Guo, Zhe& Pan, Rui-Yuan& Qin, Xiao-Yan. 2013. Potential Protection of Coeloglossum viride var. Bracteatum Extract against Oxidative Stress in Rat Cortical Neurons. Journal of Analytical Methods in Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-463750
Modern Language Association (MLA)
Guo, Zhe…[et al.]. Potential Protection of Coeloglossum viride var. Bracteatum Extract against Oxidative Stress in Rat Cortical Neurons. Journal of Analytical Methods in Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-463750
American Medical Association (AMA)
Guo, Zhe& Pan, Rui-Yuan& Qin, Xiao-Yan. Potential Protection of Coeloglossum viride var. Bracteatum Extract against Oxidative Stress in Rat Cortical Neurons. Journal of Analytical Methods in Chemistry. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-463750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463750