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Smoking and Breast Cancer Recurrence after Breast Conservation Therapy
Joint Authors
Chagpar, Anees B.
Bishop, Jennifer D.
Lannin, Donald R.
Killelea, Brigid K.
Horowitz, Nina R.
Source
International Journal of Breast Cancer
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Prior studies have shown earlier recurrence and decreased survival in patients with head and neck cancer who smoked while undergoing radiation therapy.
The purpose of the current study was to determine whether smoking status at the time of partial mastectomy and radiation therapy for breast cancer affected recurrence or survival.
Method.
A single institution retrospective chart review was performed to correlate smoking status with patient demographics, tumor characteristics, and outcomes for patients undergoing partial mastectomy and radiation therapy.
Results.
There were 624 patients who underwent breast conservation surgery between 2002 and 2010 for whom smoking history and follow-up data were available.
Smoking status was associated with race, patient age, and tumor stage, but not with grade, histology, or receptor status.
African American women were more likely to be current smokers (22% versus 7%, P<0.001).
With a mean follow-up of 45 months, recurrence was significantly higher in current smokers compared to former or never smokers (P=0.039).
In a multivariate model adjusted for race and tumor stage, recurrence among current smokers was 6.7 times that of never smokers (CI 2.0–22.4).
Conclusions.
Although the numbers are small, this study suggests that smoking may negatively influence recurrence rates after partial mastectomy and radiation therapy.
A larger study is needed to confirm these observations.
American Psychological Association (APA)
Bishop, Jennifer D.& Killelea, Brigid K.& Chagpar, Anees B.& Horowitz, Nina R.& Lannin, Donald R.. 2014. Smoking and Breast Cancer Recurrence after Breast Conservation Therapy. International Journal of Breast Cancer،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-463792
Modern Language Association (MLA)
Bishop, Jennifer D.…[et al.]. Smoking and Breast Cancer Recurrence after Breast Conservation Therapy. International Journal of Breast Cancer No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-463792
American Medical Association (AMA)
Bishop, Jennifer D.& Killelea, Brigid K.& Chagpar, Anees B.& Horowitz, Nina R.& Lannin, Donald R.. Smoking and Breast Cancer Recurrence after Breast Conservation Therapy. International Journal of Breast Cancer. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-463792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463792