![](/images/graphics-bg.png)
Mitochondrial Dysfunction Induces Formation of Lipid Droplets as a Generalized Response to Stress
Joint Authors
Lee, Seon-Jin
Choi, Augustine M. K.
Zhang, Jinglan
Kim, Hong Pyo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Lipid droplet (LD) formation is a hallmark of cellular stress.
Cells attempt to combat noxious stimuli by switching their metabolism from oxidative phosphorylation to glycolysis, sparing resources in LDs for generating cellular reducing power and for anabolic biosynthesis.
Membrane phospholipids are also a source of LDs.
To elucidate the formation of LDs, we exposed mice to hyperoxia, hypoxia, myocardial ischemia, and sepsis induced by cecal ligation and puncture (CLP).
All the above-mentioned stressors enhanced the formation of LDs, as assessed by transmission electron microscopy, with severe mitochondrial swelling.
Disruption of mitochondria by depleting mitochondrial DNA (ρ0 cells) significantly augmented the formation of LDs, causing transcriptional activation of fatty acid biosynthesis and metabolic reprogramming to glycolysis.
Heme oxygenase (HO)-1 counteracts CLP-mediated septic shock in mouse models.
In HO-1-deficient mice, LD formation was not observed upon CLP, but a concomitant decrease in “LD-decorating proteins” was observed, implying a link between LDs and cytoprotective activity.
Collectively, LD biogenesis during stress can trigger adaptive LD formation, which is dependent on mitochondrial integrity and HO-1 activity; this may be a cellular survival strategy, apportioning energy-generating substrates to cellular defense.
American Psychological Association (APA)
Lee, Seon-Jin& Zhang, Jinglan& Choi, Augustine M. K.& Kim, Hong Pyo. 2013. Mitochondrial Dysfunction Induces Formation of Lipid Droplets as a Generalized Response to Stress. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-463803
Modern Language Association (MLA)
Lee, Seon-Jin…[et al.]. Mitochondrial Dysfunction Induces Formation of Lipid Droplets as a Generalized Response to Stress. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-463803
American Medical Association (AMA)
Lee, Seon-Jin& Zhang, Jinglan& Choi, Augustine M. K.& Kim, Hong Pyo. Mitochondrial Dysfunction Induces Formation of Lipid Droplets as a Generalized Response to Stress. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-463803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463803