Castration-Resistant Prostate Cancer : Mechanisms, Targets, and Treatment

Abstract EN

Patients with castration-resistant prostate cancer (CRPC), who progress after docetaxel therapy, had until very recently, only a few therapeutic options.

Recent advances in this field brought about new perspectives in the treatment of this disease.

Molecular, basic, and translational research has given us a better understanding on the mechanisms of CRPC.

This great investment has turned into a more rational approach to the development of new drugs.

Some of the new treatments are already available to our patients outside clinical trials and may include inhibitors of androgen biosynthesis; new chemotherapy agents; bone-targeted therapy; and immunotherapy.

This paper aims to review the mechanisms of prostate cancer resistance, possible therapeutic targets, as well as new options to treat CRPC.