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A Controversial Role for IL-12 in Immune Response and Bone Resorption at Apical Periodontal Sites
Joint Authors
Cunha, Fernando Queiroz
Silva, Marcelo José Barbosa
Silva, Tarcília Aparecida da
Queiroz-Junior, Celso Martins
Teixeira, Mauro Martins
Madeira, Mila Fernandes Moreira
Garlet, Gustavo Pompermaier
Corrêa, Jôice Dias
Garlet, Thiago Pompermaier
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Periapical lesions are inflammatory conditions of tooth periapical tissues, triggered by dental pulp infection and characterized by exudation of immune cells to the affected tissues and production of inflammatory mediators such as cytokines.
The inflammatory periapical reaction is mainly driven by Th1, Th2, and Th17 responses, and such polarization may modulate progression of the disease and expression of bone proresorptive cytokines.
IL-12 is a potent inducer of IFN-γ production, which stimulates Th1 effector cells.
Many evidences have shown a positive correlation between the bone resorptive cytokine IL-1β and the production of IL-12 and IFN-γ.
Furthermore, IL-12 may have a potential role in the release of bone resorptive mediators and blockade of Th2 cytokines, affecting the progression of periapical bone loss.
Nevertheless, IL-12 and IFN-γ have also been described as suppressors of osteoclast differentiation and activation, favoring bone maintenance.
This paper focuses on the controversial roles of IL-12 in periapical lesions.
American Psychological Association (APA)
Queiroz-Junior, Celso Martins& Silva, Marcelo José Barbosa& Corrêa, Jôice Dias& Madeira, Mila Fernandes Moreira& Garlet, Thiago Pompermaier& Garlet, Gustavo Pompermaier…[et al.]. 2011. A Controversial Role for IL-12 in Immune Response and Bone Resorption at Apical Periodontal Sites. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-463838
Modern Language Association (MLA)
Queiroz-Junior, Celso Martins…[et al.]. A Controversial Role for IL-12 in Immune Response and Bone Resorption at Apical Periodontal Sites. Clinical and Developmental Immunology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-463838
American Medical Association (AMA)
Queiroz-Junior, Celso Martins& Silva, Marcelo José Barbosa& Corrêa, Jôice Dias& Madeira, Mila Fernandes Moreira& Garlet, Thiago Pompermaier& Garlet, Gustavo Pompermaier…[et al.]. A Controversial Role for IL-12 in Immune Response and Bone Resorption at Apical Periodontal Sites. Clinical and Developmental Immunology. 2011. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-463838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463838