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Therapeutic Implications of Targeting AKT Signaling in Melanoma
Joint Authors
Robertson, Gavin P.
Madhunapantula, SubbaRao V.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-23
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Identification of key enzymes regulating melanoma progression and drug resistance has the potential to lead to the development of novel, more effective targeted agents for inhibiting this deadly form of skin cancer.
The Akt3, also known as protein kinase B gamma, pathway enzymes regulate diverse cellular processes including proliferation, survival, and invasion thereby promoting the development of melanoma.
Accumulating preclinical evidence demonstrates that therapeutic agents targeting these kinases alone or in combination with other pathway members could be effective for the long-term treatment of advanced-stage disease.
However, currently, no selective and effective therapeutic agent targeting these kinases has been identified for clinical use.
This paper provides an overview of the key enzymes of the PI3K pathway with emphasis placed on Akt3 and the negative regulator of this kinase called PTEN (phosphatase and tensin homolog deleted on chromosome 10).
Mechanisms regulating these enzymes, their substrates and therapeutic implications of targeting these proteins to treat melanoma are also discussed.
Finally, key issues that remain to be answered and future directions for interested researchers pertaining to this signaling cascade are highlighted.
American Psychological Association (APA)
Madhunapantula, SubbaRao V.& Robertson, Gavin P.. 2011. Therapeutic Implications of Targeting AKT Signaling in Melanoma. Enzyme Research،Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-463880
Modern Language Association (MLA)
Madhunapantula, SubbaRao V.& Robertson, Gavin P.. Therapeutic Implications of Targeting AKT Signaling in Melanoma. Enzyme Research No. 2011 (2011), pp.1-20.
https://search.emarefa.net/detail/BIM-463880
American Medical Association (AMA)
Madhunapantula, SubbaRao V.& Robertson, Gavin P.. Therapeutic Implications of Targeting AKT Signaling in Melanoma. Enzyme Research. 2011. Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-463880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463880