Computational Simulations to Predict Creatine Kinase-Associated Factors : Protein-Protein Interaction Studies of Brain and Muscle Types of Creatine Kinases
Joint Authors
Hu, Wei-Jiang
Zhou, Sheng-Mei
Yang, Joshua SungWoo
Meng, Fan-Guo
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Creatine kinase (CK; EC 2.7.3.2) is related to several skin diseases such as psoriasis and dermatomyositis.
CK is important in skin energy homeostasis because it catalyzes the reversible transfer of a phosphoryl group from MgATP to creatine.
In this study, we predicted CK binding proteins via the use of bioinformatic tools such as protein-protein interaction (PPI) mappings and suggest the putative hub proteins for CK interactions.
We obtained 123 proteins for brain type CK and 85 proteins for muscle type CK in the interaction networks.
Among them, several hub proteins such as NFKB1, FHL2, MYOC, and ASB9 were predicted.
Determination of the binding factors of CK can further promote our understanding of the roles of CK in physiological conditions.
American Psychological Association (APA)
Hu, Wei-Jiang& Zhou, Sheng-Mei& Yang, Joshua SungWoo& Meng, Fan-Guo. 2011. Computational Simulations to Predict Creatine Kinase-Associated Factors : Protein-Protein Interaction Studies of Brain and Muscle Types of Creatine Kinases. Enzyme Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-463906
Modern Language Association (MLA)
Hu, Wei-Jiang…[et al.]. Computational Simulations to Predict Creatine Kinase-Associated Factors : Protein-Protein Interaction Studies of Brain and Muscle Types of Creatine Kinases. Enzyme Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-463906
American Medical Association (AMA)
Hu, Wei-Jiang& Zhou, Sheng-Mei& Yang, Joshua SungWoo& Meng, Fan-Guo. Computational Simulations to Predict Creatine Kinase-Associated Factors : Protein-Protein Interaction Studies of Brain and Muscle Types of Creatine Kinases. Enzyme Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-463906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463906