The MAPK MEK12-ERK12 Pathway and Its Implication in Hepatocyte Cell Cycle Control

Joint Authors

Guégan, Jean-Philippe
Baffet, Georges
Frémin, Christophe

Source

International Journal of Hepatology

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-10-24

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Medicine

Abstract EN

Primary cultures of hepatocytes are powerful models in studying the sequence of events that are necessary for cell progression from a G0-like state to S phase.

The models mimic the physiological process of hepatic regeneration after liver injury or partial hepatectomy.

Many reports suggest that the mitogen-activated protein kinase (MAPK) ERK1/2 can support hepatocyte proliferation in vitro and in vivo and the MEK/ERK cascade acts as an essential element in hepatocyte responses induced by the EGF.

Moreover, its disregulation has been associated with the promotion of tumor cell growth of a variety of tumors, including hepatocellular carcinoma.

Whereas the strict specificity of action of ERK1 and ERK2 is still debated, the MAPKs may have specific biological functions under certain contexts and according to the differentiation status of the cells, notably hepatocytes.

In this paper, we will focus on MEK1/2-ERK1/2 activations and roles in normal rodent hepatocytes in vitro and in vivo after partial hepatectomy and in human hepatocarcinoma cells.

The possible specificity of ERK1 and ERK2 in normal and transformed hepatocyte will be discussed in regard to other differentiated and undifferentiated cellular models.

American Psychological Association (APA)

Guégan, Jean-Philippe& Frémin, Christophe& Baffet, Georges. 2012. The MAPK MEK12-ERK12 Pathway and Its Implication in Hepatocyte Cell Cycle Control. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-463916

Modern Language Association (MLA)

Guégan, Jean-Philippe…[et al.]. The MAPK MEK12-ERK12 Pathway and Its Implication in Hepatocyte Cell Cycle Control. International Journal of Hepatology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-463916

American Medical Association (AMA)

Guégan, Jean-Philippe& Frémin, Christophe& Baffet, Georges. The MAPK MEK12-ERK12 Pathway and Its Implication in Hepatocyte Cell Cycle Control. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-463916

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-463916