The MAPK MEK12-ERK12 Pathway and Its Implication in Hepatocyte Cell Cycle Control
Joint Authors
Guégan, Jean-Philippe
Baffet, Georges
Frémin, Christophe
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Primary cultures of hepatocytes are powerful models in studying the sequence of events that are necessary for cell progression from a G0-like state to S phase.
The models mimic the physiological process of hepatic regeneration after liver injury or partial hepatectomy.
Many reports suggest that the mitogen-activated protein kinase (MAPK) ERK1/2 can support hepatocyte proliferation in vitro and in vivo and the MEK/ERK cascade acts as an essential element in hepatocyte responses induced by the EGF.
Moreover, its disregulation has been associated with the promotion of tumor cell growth of a variety of tumors, including hepatocellular carcinoma.
Whereas the strict specificity of action of ERK1 and ERK2 is still debated, the MAPKs may have specific biological functions under certain contexts and according to the differentiation status of the cells, notably hepatocytes.
In this paper, we will focus on MEK1/2-ERK1/2 activations and roles in normal rodent hepatocytes in vitro and in vivo after partial hepatectomy and in human hepatocarcinoma cells.
The possible specificity of ERK1 and ERK2 in normal and transformed hepatocyte will be discussed in regard to other differentiated and undifferentiated cellular models.
American Psychological Association (APA)
Guégan, Jean-Philippe& Frémin, Christophe& Baffet, Georges. 2012. The MAPK MEK12-ERK12 Pathway and Its Implication in Hepatocyte Cell Cycle Control. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-463916
Modern Language Association (MLA)
Guégan, Jean-Philippe…[et al.]. The MAPK MEK12-ERK12 Pathway and Its Implication in Hepatocyte Cell Cycle Control. International Journal of Hepatology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-463916
American Medical Association (AMA)
Guégan, Jean-Philippe& Frémin, Christophe& Baffet, Georges. The MAPK MEK12-ERK12 Pathway and Its Implication in Hepatocyte Cell Cycle Control. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-463916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463916