(Radio)Biological Optimization of External-Beam Radiotherapy
Joint Authors
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
“Biological optimization” (BIOP) means planning treatments using (radio)biological criteria and models, that is, tumour control probability and normal-tissue complication probability.
Four different levels of BIOP are identified: Level I is “isotoxic” individualization of prescription dose Dpresc at fixed fraction number.
Dpresc is varied to keep the NTCP of the organ at risk constant.
Significant improvements in local control are expected for non-small-cell lung tumours.
Level II involves the determination of an individualized isotoxic combination of Dpresc and fractionation scheme.
This approach is appropriate for “parallel” OARs (lung, parotids).
Examples are given using our BioSuite software.
Hypofractionated SABR for early-stage NSCLC is effectively Level-II BIOP.
Level-III BIOP uses radiobiological functions as part of the inverse planning of IMRT, for example, maximizing TCP whilst not exceeding a given NTCP.
This results in non-uniform target doses.
The NTCP model parameters (reflecting tissue “architecture”) drive the optimizer to emphasize different regions of the DVH, for example, penalising high doses for quasi-serial OARs such as rectum.
Level-IV BIOP adds functional imaging information, for example, hypoxia or clonogen location, to Level III; examples are given of our prostate “dose painting” protocol, BioProp.
The limitations of and uncertainties inherent in the radiobiological models are emphasized.
American Psychological Association (APA)
Nahum, Alan E.& Uzan, Julien. 2012. (Radio)Biological Optimization of External-Beam Radiotherapy. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-463997
Modern Language Association (MLA)
Nahum, Alan E.& Uzan, Julien. (Radio)Biological Optimization of External-Beam Radiotherapy. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-463997
American Medical Association (AMA)
Nahum, Alan E.& Uzan, Julien. (Radio)Biological Optimization of External-Beam Radiotherapy. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-463997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463997