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Erythropoiesis and Iron Sulfur Cluster Biogenesis
Joint Authors
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Erythropoiesis in animals is a synchronized process of erythroid cell differentiation that depends on successful acquisition of iron.
Heme synthesis depends on iron through its dependence on iron sulfur (Fe-S) cluster biogenesis.
Here, we review the relationship between Fe-S biogenesis and heme synthesis in erythropoiesis, with emphasis on the proteins, GLRX5, ABCB7, ISCA, and C1orf69.
These Fe-S biosynthesis proteins are highly expressed in erythroid tissues, and deficiency of each of these proteins has been shown to cause anemia in zebrafish model.
GLRX5 is involved in the production and ABCB7 in the export of an unknown factor that may function as a gauge of mitochondrial iron status, which may indirectly modulate activity of iron regulatory proteins (IRPs).
ALAS2, the enzyme catalyzing the first step in heme synthesis, is translationally controlled by IRPs.
GLRX5 may also provide Fe-S cofactor for ferrochelatase, the last enzyme in heme synthesis.
ISCA and C1orf69 are thought to assemble Fe-S clusters for mitochondrial aconitase and for lipoate synthase, the enzyme producing lipoate for pyruvate dehydrogenase complex (PDC).
PDC and aconitase are involved in the production of succinyl-CoA, a substrate for heme biosynthesis.
Thus, many steps of heme synthesis depend on Fe-S cluster assembly.
American Psychological Association (APA)
Ye, Hong& Rouault, Tracey A.. 2010. Erythropoiesis and Iron Sulfur Cluster Biogenesis. Advances in Hematology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-464015
Modern Language Association (MLA)
Ye, Hong& Rouault, Tracey A.. Erythropoiesis and Iron Sulfur Cluster Biogenesis. Advances in Hematology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-464015
American Medical Association (AMA)
Ye, Hong& Rouault, Tracey A.. Erythropoiesis and Iron Sulfur Cluster Biogenesis. Advances in Hematology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-464015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464015